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Actos (Pioglitazone)

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Actos (Pioglitazone) is used to treat type 2 diabetes by reducing the resistance your body has to insulin. It is used either alone or in combination with other anti-diabetes medicines including metformin or insulin as part of a diet and exercise program.

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About Actos (Pioglitazone):

Product Type: Diabetes

Brand name: Actos Generic name: Pioglitazone What is the most important information I should know about Actos? • Usually liver function is monitored with blood tests at the start of treatment every two months for the first year of treatment and periodically thereafter during treatment with Actos. Notify your doctor immediately if you develop nausea vomiting abdominal pain unusual fatigue loss of appetite yellow skin or eyes or dark urine. These symptoms may be early signs of liver problems. • Notify your doctor immediately if you experience an unusually rapid increase in weight or edema (water retention) shortness of breath or chest pain during treatment with Actos. These may be early symptoms of heart problems. • Actos usually does not cause hypoglycemia (low blood sugar). However hypoglycemia may occur as a result of skipped meals excessive exercise or alcohol consumption while taking Actos. Know the signs and symptoms of hypoglycemia which include headache drowsiness weakness dizziness fast heartbeat sweating tremor and nausea. Carry non-dietetic hard candy or glucose tablets with you to treat episodes of low blood sugar. • Actos may decrease the effects of some birth control pills. Additional measures may be necessary to prevent pregnancy while taking Actos. Talk to your doctor about the use of birth control. What is Actos? • Actos is an antihyperglycemic agent. It helps the body respond better to insulin and it reduces the amount of sugar produced by the liver. It can help control blood sugar levels. • Actos is used along with diet and exercise in the treatment of type 2 diabetes. Actos may also be used with a sulfonylurea (e.g. Diabeta Glucotrol Micronase others) metformin (Glucophage) or insulin when diet and exercise plus any one of these medicines alone do not result in adequate blood sugar control. • Actos may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking Actos? • Do not take Actos without first talking to your doctor if you have liver disease. • Before taking this medication tell your doctor if you have heart failure or heart disease; have edema (water retention or swelling); have type 1 diabetes mellitus; have a serious infection illness or injury; or need surgery. • You may not be able to take Actos or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. • Contact your doctor if you develop a fever or an infection require surgery or if you experience a serious injury. Illness or injury may cause a loss of blood sugar control and insulin (or an adjustment of a current insulin dose) may be required for a period of time. • Treatment with Actos may cause resumption of fertility by allowing for the return of ovulation (production of eggs) in certain women with insulin resistance who were not ovulating before treatment with Actos. Talk to your doctor about adequate forms of birth control while taking Actos if birth control is desired. • Actos is in the FDA pregnancy category C. This means that it is not known whether Actos will be harmful to an unborn baby. Generally insulin is the drug of choice for controlling diabetes during pregnancy. Do not take Actos without first talking to your doctor if you are pregnant or could become pregnant during treatment. • It is not known whether Actos passes into breast milk. Do not take Actos without first talking to your doctor if you are breast-feeding a baby. • The safety and effectiveness of Actos have not been established for children. How should I take Actos? • Take Actos exactly as directed by your doctor. If you do not understand these instructions ask your pharmacist nurse or doctor to explain them to you. • Take each dose with a full glass of water. • Actos can be taken with or without food or meals. • It is important to take Actos regularly to get the most benefit. • Your doctor may want you to have blood or urine tests or other medical evaluations during treatment with Actos to monitor blood sugar levels liver function or other factors. • Usually liver function is monitored with blood tests at the start of treatment every two months for the first year of treatment and periodically thereafter during treatment with Actos. Notify your doctor immediately if you develop nausea vomiting abdominal pain unusual fatigue loss of appetite yellow skin or eyes or dark urine. These symptoms may be early signs of liver problems. • Although Actos does not usually cause hypoglycemia (low blood sugar) hypoglycemia may result from skipped meals excessive exercise or alcohol consumption. Know the signs and symptoms of hypoglycemia which include headache drowsiness weakness dizziness fast heartbeat sweating tremor and nausea. Carry a piece of non-dietetic hard candy or glucose tablets with you to treat episodes of low blood sugar. • Store Actos at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. If you do not remember until the next day skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose. What happens if I overdose? • Seek emergency medical attention if an overdose is suspected. • Symptoms of a Actos overdose are not known. What should I avoid while taking Actos? • Follow any diet medication and exercise routines closely. Changing any of these factors can affect blood sugar levels. • Avoid alcohol. It lowers blood sugar and may interfere with diabetes treatment. • Tell your doctor and dentist that you are taking this medication before having surgery. • Do not take over-the-counter or prescription cough cold allergy pain or weight-loss medications during treatment with Actos without first talking to your doctor. What are the possible side effects of Actos? • If you experience any of the following serious side effects stop taking Actos and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips tongue or face; or hives); nausea vomiting abdominal pain or loss of appetite; unusual fatigue; yellowing of the skin or eyes; or dark urine. • Notify your doctor immediately if you experience an unusually rapid increase in weight or edema (swelling water retention) shortness of breath or chest pain during treatment with Actos. These may be early symptoms of heart problems. • Although Actos does not usually cause hypoglycemia (low blood sugar) hypoglycemia may result from skipped meals excessive exercise or alcohol consumption. Know the signs and symptoms of hypoglycemia which include headache drowsiness weakness dizziness fast heartbeat sweating tremor and nausea. Carry a piece of non-dietetic hard candy or glucose tablets with you to treat episodes of low blood sugar. • Other less serious side effects may also occur. Continue to take Actos and talk to your doctor if you experience: headache; muscle aches; or sore throat nasal discharge or cold symptoms. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Actos? • Actos may decrease the effects of some birth control pills. Additional measures may be necessary to prevent pregnancy while taking Actos. Talk to your doctor about the use of birth control. • Do not take over-the-counter or prescription cough cold allergy pain or weight-loss medications during treatment with Actos without first talking to your doctor. • Drugs other than those listed here may also interact with Actos or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins minerals and herbal products.

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What should I discuss with my healthcare provider before taking Arava? • Before taking Arava tell your doctor if you have liver disease or a history of hepatitis; a history of significant alcohol use; kidney disease; an immune system disease; recently received a live vaccine; poor bone marrow function; or a current or chronic infection. • You may not be able to take Arava or you may require a dosage adjustment or special monitoring during your treatment if you have any of the conditions listed above. • Arava is in the FDA pregnancy category X. There is an increased risk of birth defects and death of the unborn baby while taking Arava. Do not take this medication if you are pregnant or could become pregnant during treatment. Notify your doctor immediately if you think you have become pregnant during treatment. Birth control must be used during treatment with Arava. Discuss with your doctor the procedure for removing Arava from the body following treatment before becoming pregnant. Without the proper drug elimination procedure it may take up to two years before Arava is at sufficiently low levels in the body so as to reduce the risk of harm to an unborn baby. It is not known whether Arava imposes an increased risk of fetal harm when taken by a man. Men wishing to father a child while taking Arava should discuss their options with their doctor. • It is not known whether Arava passes into breast milk. There is a potential for serious side effects in a nursing baby from Arava. Do not take Arava if you are breast-feeding a baby. How should I take Arava? • Take Arava exactly as directed by your doctor. If you do not understand these instructions ask your pharmacist nurse or doctor to explain them to you. • Take each dose with a full glass of water. • Arava can be taken with or without food or milk. • It is important to take Arava regularly to get the most benefit. • Your doctor may want you to have blood tests or other medical evaluations while taking Arava to monitor side effects and progress. • Store Arava at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. If it is almost time for your next dose skip the missed dose and only take your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? • Seek emergency medical attention if an overdose is suspected. • Symptoms of a Arava overdose may include diarrhea abdominal pain blood problems and liver problems. 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What are the possible side effects of Arava? • If you experience any of the following serious side effects stop taking Arava and seek medical treatment or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips tongue or face; or hives); changes in liver function (may be detected by blood tests or cause symptoms such as yellowing of the skin or eyes; pale colored stools or dark colored urine; unusual fatigue; or abdominal pain); decreased bone marrow function or blood problems (may be detected by blood tests or cause symptoms such as extreme or unusual fatigue; easy bruising or bleeding; black bloody or tarry stools; fever or chills; or signs of infection such as fever; chills or sore throat); or skin rash; or sores in the mouth. • Other less serious side effects may be more likely to occur. Continue to take Arava and talk to your doctor if you experience headache; increased blood pressure; muscle aches; nausea; diarrhea; or hair loss. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Arava? • Before taking Arava tell your doctor if you are taking any of the following drugs: cholestyramine (Questran Prevalite LoCHOLEST); methotrexate (Rheumatrex); or rifampin (Rifadin Rimactane). • You may not be able to take Arava or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. • Drugs other than those listed here may also interact with Arava. 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